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The genetic design of signaling cascades to record receptor activation
We have developed an experimental strategy to monitor protein interactions in a cell with a high degree of selectivity and sensitivity. A transcription factor is tethered to a membrane-bound receptor with a linker that contains a cleavage site for a specific protease. Activation of the receptor recr...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2224232/ https://ncbi.nlm.nih.gov/pubmed/18165312 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0710487105 |
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