Transgenic system for conditional induction and rescue of chronic myocardial hibernation provides insights into genomic programs of hibernation

A key energy-saving adaptation to chronic hypoxia that enables cardiomyocytes to withstand severe ischemic insults is hibernation, i.e., a reversible arrest of contractile function. Whereas hibernating cardiomyocytes represent the critical reserve of dysfunctional cells that can be potentially rescu...

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Bibliographische Detailangaben
Hauptverfasser: May, Dalit, Gilon, Dan, Djonov, Valentin, Itin, Ahuva, Lazarus, Alon, Gordon, Oren, Rosenberger, Christian, Keshet, Eli
Format: Artigo
Sprache:Inglês
Veröffentlicht: National Academy of Sciences 2008
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2224202/
https://ncbi.nlm.nih.gov/pubmed/18162550
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0707778105
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