A Transgenic Platform for Testing Drugs Intended for Reversal of Cardiac Remodeling Identifies a Novel 11βHSD1 Inhibitor Rescuing Hypertrophy Independently of Re-Vascularization

RATIONALE: Rescuing adverse myocardial remodeling is an unmet clinical goal and, correspondingly, pharmacological means for its intended reversal are urgently needed. OBJECTIVES: To harness a newly-developed experimental model recapitulating progressive heart failure development for the discovery of...

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Bibliografiska uppgifter
Huvudupphovsmän: Gordon, Oren, He, Zhiheng, Gilon, Dan, Gruener, Sabine, Pietranico-Cole, Sherrie, Oppenheim, Amit, Keshet, Eli
Materialtyp: Artigo
Språk:Inglês
Publicerad: Public Library of Science 2014
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC3965501/
https://ncbi.nlm.nih.gov/pubmed/24667808
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0092869
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