Immunocytochemical analysis of cisplatin-induced platinum-DNA adducts with double-fluorescence video microscopy.

To detect low-level DNA platination, a sensitive immunocyto- and histochemical technique was developed using a polyclonal antibody. The antibody GPt, derived after immunization of rabbits with highly platinated DNA and purified with affinity chromatography, detected the main platinum (Pt)-containing...

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Autors principals: Meijer, C., de Vries, E. G., Dam, W. A., Wilkinson, M. H., Hollema, H., Hoekstra, H. J., Mulder, N. H.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group 1997
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2224054/
https://ncbi.nlm.nih.gov/pubmed/9252194
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