Intrapulmonary Distribution of Intravenous Telavancin in Healthy Subjects and Effect of Pulmonary Surfactant on In Vitro Activities of Telavancin and Other Antibiotics

Steady-state concentrations of telavancin, a novel, bactericidal lipoglycopeptide, were determined in the plasma, pulmonary epithelial lining fluid (ELF), and alveolar macrophages (AMs) of 20 healthy subjects. Telavancin at 10 mg of drug/kg of body weight/day was administered as a 1-h intravenous in...

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Main Authors: Gotfried, Mark H., Shaw, Jeng-Pyng, Benton, Bret M., Krause, Kevin M., Goldberg, Michael R., Kitt, Michael M., Barriere, Steven L.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology (ASM) 2008
Assuntos:
Pharmacology
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2223919/
https://ncbi.nlm.nih.gov/pubmed/17923490
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00875-07
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