Interactions of Methylene Blue with Human Disulfide Reductases and Their Orthologues from Plasmodium falciparum

Methylene blue (MB) has experienced a renaissance mainly as a component of drug combinations against Plasmodium falciparum malaria. Here, we report biochemically relevant pharmacological data on MB such as rate constants for the uncatalyzed reaction of MB at pH 7.4 with cellular reductants like NAD(...

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Main Authors: Buchholz, Kathrin, Schirmer, R. Heiner, Eubel, Jana K., Akoachere, Monique B., Dandekar, Thomas, Becker, Katja, Gromer, Stephan
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology (ASM) 2008
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Mechanisms of Action: Physiological Effects
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2223905/
https://ncbi.nlm.nih.gov/pubmed/17967916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00773-07
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