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Cytotoxicity in Macrophages Infected with Rough Brucella Mutants Is Type IV Secretion System Dependent
Smooth Brucella spp. inhibit macrophage apoptosis, whereas rough Brucella mutants induce macrophage oncotic and necrotic cell death. However, the mechanisms and genes responsible for Brucella cytotoxicity have not been identified. In the current study, a random mutagenesis approach was used to creat...
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| Autors principals: | , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Microbiology (ASM)
2008
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2223635/ https://ncbi.nlm.nih.gov/pubmed/17938217 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00379-07 |
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