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Cytotoxicity in Macrophages Infected with Rough Brucella Mutants Is Type IV Secretion System Dependent

Smooth Brucella spp. inhibit macrophage apoptosis, whereas rough Brucella mutants induce macrophage oncotic and necrotic cell death. However, the mechanisms and genes responsible for Brucella cytotoxicity have not been identified. In the current study, a random mutagenesis approach was used to creat...

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Bibliografiske detaljer
Main Authors: Pei, Jianwu, Wu, Qingmin, Kahl-McDonagh, Melissa, Ficht, Thomas A.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2008
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2223635/
https://ncbi.nlm.nih.gov/pubmed/17938217
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00379-07
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