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Mutations in the Tryptophan Operon Allow PurF-Independent Thiamine Synthesis by Altering Flux In Vivo

Phosphoribosyl amine (PRA) is an intermediate in purine biosynthesis and also required for thiamine biosynthesis in Salmonella enterica. PRA is normally synthesized by phosphoribosyl pyrophosphate amidotransferase, a high-turnover enzyme of the purine biosynthetic pathway encoded by purF. However, P...

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Detalhes bibliográficos
Main Authors: Ramos, Itzel, Vivas, E. I., Downs, D. M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2008
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2223571/
https://ncbi.nlm.nih.gov/pubmed/17557816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.00582-07
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