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Mutations in the Tryptophan Operon Allow PurF-Independent Thiamine Synthesis by Altering Flux In Vivo

Phosphoribosyl amine (PRA) is an intermediate in purine biosynthesis and also required for thiamine biosynthesis in Salmonella enterica. PRA is normally synthesized by phosphoribosyl pyrophosphate amidotransferase, a high-turnover enzyme of the purine biosynthetic pathway encoded by purF. However, P...

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書目詳細資料
Main Authors: Ramos, Itzel, Vivas, E. I., Downs, D. M.
格式: Artigo
語言:Inglês
出版: American Society for Microbiology (ASM) 2008
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2223571/
https://ncbi.nlm.nih.gov/pubmed/17557816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.00582-07
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