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Mutations in the Tryptophan Operon Allow PurF-Independent Thiamine Synthesis by Altering Flux In Vivo

Phosphoribosyl amine (PRA) is an intermediate in purine biosynthesis and also required for thiamine biosynthesis in Salmonella enterica. PRA is normally synthesized by phosphoribosyl pyrophosphate amidotransferase, a high-turnover enzyme of the purine biosynthetic pathway encoded by purF. However, P...

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Bibliografske podrobnosti
Main Authors: Ramos, Itzel, Vivas, E. I., Downs, D. M.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology (ASM) 2008
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2223571/
https://ncbi.nlm.nih.gov/pubmed/17557816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.00582-07
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