Induction of p16 during immortalization by HPV 16 and 18 and not during malignant transformation.

The p16 (MTS1) tumour-suppressor gene is a cyclin-dependent kinase (cdk) inhibitor that decelerates the cell cycle by inactivating the cdks that phosphorylate the retinoblastoma tumour-suppressor gene (Rb) protein (pRb). In cervical cancers, pRb is inactivated by the HPV E7 oncoprotein or by mutatio...

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Main Authors: Nakao, Y., Yang, X., Yokoyama, M., Ferenczy, A., Tang, S. C., Pater, M. M., Pater, A.
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group 1997
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2223509/
https://ncbi.nlm.nih.gov/pubmed/9166931
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