Stepwise immortalization and transformation of adult human prostate epithelial cells by a combination of HPV-18 and v-Ki-ras.

Recent investigations have shown the presence of ras gene mutations and human papillomavirus (HPV) DNA in prostate carcinomas. In the present study, secondary adult human prostatic epithelial cells, upon transfection with a plasmid containing the entire HPV-18 genome, acquired an indefinite life-spa...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Rhim, J S, Webber, M M, Bello, D, Lee, M S, Arnstein, P, Chen, L S, Jay, G
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1994
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC45338/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7991549/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.25.11874
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