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The oxidative stress adaptor p66Shc is required for permanent embryo arrest in vitro

BACKGROUND: Excessive developmental failure occurs during the first week of in vitro embryo development due to elevated levels of cell death and arrest. We hypothesize that permanently arrested embryos enter a stress-induced "senescence-like" state that is dependent on the oxidative stress...

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Detalhes bibliográficos
Main Authors: Favetta, Laura A, Madan, Pavneesh, Mastromonaco, Gabriela F, St John, Elizabeth J, King, W Allan, Betts, Dean H
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2007
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2220003/
https://ncbi.nlm.nih.gov/pubmed/18047664
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-213X-7-132
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