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Altered Ionic Selectivity of the Sodium Channel Revealed by Cysteine Mutations within the Pore
To explore the role of pore-lining amino acids in Na(+) channel ion-selectivity, pore residues were replaced serially with cysteine in cloned rat skeletal muscle Na(+) channels. Ionic selectivity was determined by measuring permeability and ionic current ratios of whole-cell currents in Xenopus ooc...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
1997
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2219431/ https://ncbi.nlm.nih.gov/pubmed/9101405 |
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