RGD-avidin–biotin pretargeting to α(v)β(3) integrin enhances the proapoptotic activity of TNFα related apoptosis inducing ligand (TRAIL)

Recombinant TNF-related apoptosis-inducing ligand (TRAIL) is considered a powerful and selective inducer of tumor cell death. We hypothesize that TRAIL’s potential as anticancer agent can be enhanced further by promoting its accumulation in tumor tissue. For this purpose, we developed TRAIL complexe...

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Autors principals: Tarrus, Marc, van der Sloot, Almer M., Temming, Kai, Lacombe, Marie, Opdam, Frank, Quax, Wim J., Molema, Grietje, Poelstra, Klaas, Kok, Robbert J.
Format: Artigo
Idioma:Inglês
Publicat: Springer US 2007
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Original Paper
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2217618/
https://ncbi.nlm.nih.gov/pubmed/18071905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10495-007-0166-5
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