RGD-avidin–biotin pretargeting to α(v)β(3) integrin enhances the proapoptotic activity of TNFα related apoptosis inducing ligand (TRAIL)

Recombinant TNF-related apoptosis-inducing ligand (TRAIL) is considered a powerful and selective inducer of tumor cell death. We hypothesize that TRAIL’s potential as anticancer agent can be enhanced further by promoting its accumulation in tumor tissue. For this purpose, we developed TRAIL complexe...

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Bibliographische Detailangaben
Hauptverfasser: Tarrus, Marc, van der Sloot, Almer M., Temming, Kai, Lacombe, Marie, Opdam, Frank, Quax, Wim J., Molema, Grietje, Poelstra, Klaas, Kok, Robbert J.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Springer US 2007
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Original Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2217618/
https://ncbi.nlm.nih.gov/pubmed/18071905
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10495-007-0166-5
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