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Cysteine Modification Alters Voltage- and Ca(2+)-dependent Gating of Large Conductance (BK) Potassium Channels

The Ca(2+)-activated K(+) (BK) channel α-subunit contains many cysteine residues within its large COOH-terminal tail domain. To probe the function of this domain, we examined effects of cysteine-modifying reagents on channel gating. Application of MTSET, MTSES, or NEM to mSlo1 or hSlo1 channels chan...

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Bibliographic Details
Main Authors: Zhang, Guangping, Horrigan, Frank T.
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2005
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2217493/
https://ncbi.nlm.nih.gov/pubmed/15684095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.200409149
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