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Negative Charges in the Transmembrane Domains of the HERG K Channel Are Involved in the Activation- and Deactivation-gating Processes

The transmembrane domains of HERG (S1–S3) contain six negative charges: three are conserved in all voltage-gated K channels (D456 and D466 in S2, D501 in S3) and three are unique to the EAG family (D411 in S1, D460 in S2, and D509 in S3). We infer the functional role of these aspartates by studying...

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Bibliografski detalji
Glavni autori: Liu, Jie, Zhang, Mei, Jiang, Min, Tseng, Gea-Ny
Format: Artigo
Jezik:Inglês
Izdano: The Rockefeller University Press 2003
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2217355/
https://ncbi.nlm.nih.gov/pubmed/12771194
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.200308788
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