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Molecular Action of Lidocaine on the Voltage Sensors of Sodium Channels
Block of sodium ionic current by lidocaine is associated with alteration of the gating charge-voltage (Q-V) relationship characterized by a 38% reduction in maximal gating charge (Q(max)) and by the appearance of additional gating charge at negative test potentials. We investigated the molecular bas...
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| Auteurs principaux: | , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
The Rockefeller University Press
2003
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2217326/ https://ncbi.nlm.nih.gov/pubmed/12566542 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.20028651 |
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