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Mechanism of Tetracaine Block of Cyclic Nucleotide-gated Channels

Local anesthetics are a diverse group of ion channel blockers that can be used to probe conformational changes in the pore. We examined the effects of the local anesthetic tetracaine on rod and olfactory cyclic nucleotide-gated channels expressed from subunit 1 in Xenopus oocytes. We found that 40 μ...

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Detalhes bibliográficos
Main Authors: Fodor, Anthony A., Gordon, Sharona E., Zagotta, William N.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 1997
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2217055/
https://ncbi.nlm.nih.gov/pubmed/8997661
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