Induction of Mrp3 and Mrp4 transporters during acetaminophen hepatotoxicity is dependent on Nrf2

The transcription factor NFE2-related factor 2 (Nrf2) mediates detoxification and antioxidant gene transcription following electrophile exposure and oxidative stress. Mice deficient in Nrf2 (Nrf2-null) are highly susceptible to acetaminophen (APAP) hepatotoxicity, and exhibit lower basal and inducib...

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Bibliographic Details
Main Authors: Aleksunes, Lauren M., Slitt, Angela L., Maher, Jonathan M., Augustine, Lisa M., Goedken, Michael, Chan, Jefferson Y., Cherrington, Nathan J., Klaassen, Curtis D., Manautou, José E.
Format: Artigo
Language:Inglês
Published: 2007
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2214834/
https://ncbi.nlm.nih.gov/pubmed/17935745
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.taap.2007.08.022
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