Nuclear factor-E2-related factor 2 expression in liver is critical for induction of NAD(P)H:quinone oxidoreductase 1 during cholestasis

Bile duct ligation (BDL) causes hepatocellular oxidative stress and injury. The transcription factor nuclear factor-E2-related factor (Nrf2) induces expression of numerous genes including NAD(P)H:quinone oxidoreductase 1 (Nqo1) during periods of oxidative stress. Therefore, we hypothesized that BDL...

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Detalhes bibliográficos
Main Authors: Aleksunes, Lauren M., Slitt, Angela L., Maher, Jonathan M., Dieter, Matthew Z., Knight, Tamara R., Goedken, Michael, Cherrington, Nathan J., Chan, Jefferson Y., Klaassen, Curtis D., Manautou, José E.
Formato: Artigo
Idioma:Inglês
Publicado em: Springer 2006
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1759988/
https://ncbi.nlm.nih.gov/pubmed/17278884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1379/CSC-217.1
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