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Hydroxyurea nitrosylates and activates soluble guanylyl cyclase in human erythroid cells
Hydroxyurea, a drug widely used for treating myeloproliferative diseases, has also been approved for the treatment of sickle cell disease by raising fetal hemoglobin (HbF). We have shown that nitric oxide (NO) and the soluble guanylyl cyclase (sGC) pathways are involved in hydroxyurea induction of H...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society of Hematology
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2214757/ https://ncbi.nlm.nih.gov/pubmed/17993617 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-05-088732 |
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