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Hydroxyurea induces fetal hemoglobin by the nitric oxide–dependent activation of soluble guanylyl cyclase

Hydroxyurea treatment of patients with sickle-cell disease increases fetal hemoglobin (HbF), which reduces hemoglobin S polymerization and clinical complications. Despite its use in the treatment of myeloproliferative diseases for over 30 years, its mechanism of action remains uncertain. Recent stud...

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Detalhes bibliográficos
Main Authors: Cokic, Vladan P., Smith, Reginald D., Beleslin-Cokic, Bojana B., Njoroge, Joyce M., Miller, Jeffery L., Gladwin, Mark T., Schechter, Alan N.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2003
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC151872/
https://ncbi.nlm.nih.gov/pubmed/12531879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200316672
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