FLT3 D835/I836 mutations are associated with poor disease-free survival and a distinct gene-expression signature among younger adults with de novo cytogenetically normal acute myeloid leukemia lacking FLT3 internal tandem duplications

The prognostic relevance of FLT3 D835/I836 mutations (FLT3-TKD) in cytogenetically normal acute myeloid leukemia (CN-AML) remains to be established. After excluding patients with FLT3 internal tandem duplications, we compared treatment outcome of 16 de novo CN-AML patients with FLT3-TKD with that of...

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Hauptverfasser: Whitman, Susan P., Ruppert, Amy S., Radmacher, Michael D., Mrózek, Krzysztof, Paschka, Peter, Langer, Christian, Baldus, Claudia D., Wen, Jing, Racke, Frederick, Powell, Bayard L., Kolitz, Jonathan E., Larson, Richard A., Caligiuri, Michael A., Marcucci, Guido, Bloomfield, Clara D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society of Hematology 2008
Schlagworte:
Neoplasia
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2214747/
https://ncbi.nlm.nih.gov/pubmed/17940205
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2007-08-107946
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