Peroxynitrite-mediated modification of proteins at physiological carbon dioxide concentration: pH dependence of carbonyl formation, tyrosine nitration, and methionine oxidation

The ability of peroxynitrite to modify amino acid residues in glutamine synthetase (GS) and BSA is greatly influenced by pH and CO(2)(.) At physiological concentrations of CO(2) (1.3 mM), the generation of carbonyl groups (0.2–0.4 equivalents/subunit) is little affected by pH over the range of 7.2–9...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Tien, Ming, Berlett, Barbara S., Levine, Rodney L., Chock, P. Boon, Stadtman, Earl R.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1999
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC22143/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10393903/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.96.14.7809
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