Peroxynitrite-mediated modification of proteins at physiological carbon dioxide concentration: pH dependence of carbonyl formation, tyrosine nitration, and methionine oxidation

The ability of peroxynitrite to modify amino acid residues in glutamine synthetase (GS) and BSA is greatly influenced by pH and CO(2)(.) At physiological concentrations of CO(2) (1.3 mM), the generation of carbonyl groups (0.2–0.4 equivalents/subunit) is little affected by pH over the range of 7.2–9...

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Hauptverfasser: Tien, Ming, Berlett, Barbara S., Levine, Rodney L., Chock, P. Boon, Stadtman, Earl R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The National Academy of Sciences 1999
Schlagworte:
Biological Sciences
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC22143/
https://ncbi.nlm.nih.gov/pubmed/10393903
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