Voltage-gated Na(v) channel targeting in the heart requires an ankyrin-G–dependent cellular pathway

Voltage-gated Na(v) channels are required for normal electrical activity in neurons, skeletal muscle, and cardiomyocytes. In the heart, Na(v)1.5 is the predominant Na(v) channel, and Na(v)1.5-dependent activity regulates rapid upstroke of the cardiac action potential. Na(v)1.5 activity requires prec...

Full description

Saved in:
Bibliographic Details
Main Authors: Lowe, John S., Palygin, Oleg, Bhasin, Naina, Hund, Thomas J., Boyden, Penelope A., Shibata, Erwin, Anderson, Mark E., Mohler, Peter J.
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2008
Subjects:
Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2213608/
https://ncbi.nlm.nih.gov/pubmed/18180363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200710107
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items