Voltage-gated Na(v) channel targeting in the heart requires an ankyrin-G–dependent cellular pathway

Voltage-gated Na(v) channels are required for normal electrical activity in neurons, skeletal muscle, and cardiomyocytes. In the heart, Na(v)1.5 is the predominant Na(v) channel, and Na(v)1.5-dependent activity regulates rapid upstroke of the cardiac action potential. Na(v)1.5 activity requires prec...

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Hlavní autoři: Lowe, John S., Palygin, Oleg, Bhasin, Naina, Hund, Thomas J., Boyden, Penelope A., Shibata, Erwin, Anderson, Mark E., Mohler, Peter J.
Médium: Artigo
Jazyk:Inglês
Vydáno: The Rockefeller University Press 2008
Témata:
Research Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2213608/
https://ncbi.nlm.nih.gov/pubmed/18180363
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200710107
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