SOD1 mutations disrupt redox-sensitive Rac regulation of NADPH oxidase in a familial ALS model

Neurodegeneration in familial amyotrophic lateral sclerosis (ALS) is associated with enhanced redox stress caused by dominant mutations in superoxide dismutase–1 (SOD1). SOD1 is a cytosolic enzyme that facilitates the conversion of superoxide (O(2)(•–)) to H(2)O(2). Here we demonstrate that SOD1 is...

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Bibliografiske detaljer
Main Authors: Harraz, Maged M., Marden, Jennifer J., Zhou, Weihong, Zhang, Yulong, Williams, Aislinn, Sharov, Victor S., Nelson, Kathryn, Luo, Meihui, Paulson, Henry, Schöneich, Christian, Engelhardt, John F.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2008
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2213375/
https://ncbi.nlm.nih.gov/pubmed/18219391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI34060
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