SOD1 mutations disrupt redox-sensitive Rac regulation of NADPH oxidase in a familial ALS model

Neurodegeneration in familial amyotrophic lateral sclerosis (ALS) is associated with enhanced redox stress caused by dominant mutations in superoxide dismutase–1 (SOD1). SOD1 is a cytosolic enzyme that facilitates the conversion of superoxide (O(2)(•–)) to H(2)O(2). Here we demonstrate that SOD1 is...

Full beskrivning

Sparad:
Bibliografiska uppgifter
Huvudupphovsmän: Harraz, Maged M., Marden, Jennifer J., Zhou, Weihong, Zhang, Yulong, Williams, Aislinn, Sharov, Victor S., Nelson, Kathryn, Luo, Meihui, Paulson, Henry, Schöneich, Christian, Engelhardt, John F.
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Clinical Investigation 2008
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2213375/
https://ncbi.nlm.nih.gov/pubmed/18219391
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI34060
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk