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SOD1 mutations disrupt redox-sensitive Rac regulation of NADPH oxidase in a familial ALS model
Neurodegeneration in familial amyotrophic lateral sclerosis (ALS) is associated with enhanced redox stress caused by dominant mutations in superoxide dismutase–1 (SOD1). SOD1 is a cytosolic enzyme that facilitates the conversion of superoxide (O(2)(•–)) to H(2)O(2). Here we demonstrate that SOD1 is...
Tallennettuna:
| Päätekijät: | , , , , , , , , , , |
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| Aineistotyyppi: | Artigo |
| Kieli: | Inglês |
| Julkaistu: |
American Society for Clinical Investigation
2008
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| Aiheet: | |
| Linkit: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2213375/ https://ncbi.nlm.nih.gov/pubmed/18219391 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI34060 |
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