The Scurfy mutation of FoxP3 in the thymus stroma leads to defective thymopoiesis

The Scurfy mutation of the FoxP3 gene (FoxP3 (sf)) in the mouse and analogous mutations in human result in lethal autoimmunity. The mutation of FoxP3 in the hematopoietic cells impairs the development of regulatory T cells. In addition, development of the Scurfy disease also may require mutation of...

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Detalhes bibliográficos
Main Authors: Chang, Xing, Gao, Jian Xin, Jiang, Qi, Wen, Jing, Seifers, Nick, Su, Lishan, Godfrey, Virginia L., Zuo, Tao, Zheng, Pan, Liu, Yang
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2005
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2213221/
https://ncbi.nlm.nih.gov/pubmed/16230479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20050157
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