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The Scurfy mutation of FoxP3 in the thymus stroma leads to defective thymopoiesis
The Scurfy mutation of the FoxP3 gene (FoxP3 (sf)) in the mouse and analogous mutations in human result in lethal autoimmunity. The mutation of FoxP3 in the hematopoietic cells impairs the development of regulatory T cells. In addition, development of the Scurfy disease also may require mutation of...
Αποθηκεύτηκε σε:
| Κύριοι συγγραφείς: | , , , , , , , , , |
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| Μορφή: | Artigo |
| Γλώσσα: | Inglês |
| Έκδοση: |
The Rockefeller University Press
2005
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| Θέματα: | |
| Διαθέσιμο Online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2213221/ https://ncbi.nlm.nih.gov/pubmed/16230479 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20050157 |
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