Role of membrane sphingomyelin and ceramide in platform formation for Fas-mediated apoptosis

Engagement of the Fas receptor (CD95) initiates multiple signaling pathways that lead to apoptosis, such as the formation of death-inducing signaling complex (DISC), activation of caspase cascades, and the generation of the lipid messenger, ceramide. Sphingomyelin (SM) is a major component of lipid...

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Main Authors: Miyaji, Michihiko, Jin, Zhe-Xiong, Yamaoka, Shohei, Amakawa, Ryuichi, Fukuhara, Shirou, Sato, Satoshi B., Kobayashi, Toshihide, Domae, Naochika, Mimori, Tsuneyo, Bloom, Eda T., Okazaki, Toshiro, Umehara, Hisanori
Formato: Artigo
Idioma:Inglês
Publicado: The Rockefeller University Press 2005
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2213006/
https://ncbi.nlm.nih.gov/pubmed/16009715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20041685
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