Regulation of Cell Migration by Sphingomyelin Synthases: Sphingomyelin in Lipid Rafts Decreases Responsiveness to Signaling by the CXCL12/CXCR4 Pathway

Sphingomyelin synthase (SMS) catalyzes the formation of sphingomyelin, a major component of the plasma membrane and lipid rafts. To investigate the role of SMS in cell signaling and migration induced by binding of the chemokine CXCL12 to CXCR4, we used mouse embryonic fibroblasts deficient in SMS1 a...

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Main Authors: Asano, Satoshi, Kitatani, Kazuyuki, Taniguchi, Makoto, Hashimoto, Mayumi, Zama, Kota, Mitsutake, Susumu, Igarashi, Yasuyuki, Takeya, Hiroyuki, Kigawa, Junzo, Hayashi, Akira, Umehara, Hisanori, Okazaki, Toshiro
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2012
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3434554/
https://ncbi.nlm.nih.gov/pubmed/22688512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00121-12
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