Regulation of Autophagy and Its Associated Cell Death by “Sphingolipid Rheostat”: RECIPROCAL ROLE OF CERAMIDE AND SPHINGOSINE 1-PHOSPHATE IN THE MAMMALIAN TARGET OF RAPAMYCIN PATHWAY

The role of “sphingolipid rheostat” by ceramide and sphingosine 1-phosphate (S1P) in the regulation of autophagy remains unclear. In human leukemia HL-60 cells, amino acid deprivation (AA(−)) caused autophagy with an increase in acid sphingomyleinase (SMase) activity and ceramide, which serves as an...

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Библиографические подробности
Главные авторы: Taniguchi, Makoto, Kitatani, Kazuyuki, Kondo, Tadakazu, Hashimoto-Nishimura, Mayumi, Asano, Satoshi, Hayashi, Akira, Mitsutake, Susumu, Igarashi, Yasuyuki, Umehara, Hisanori, Takeya, Hiroyuki, Kigawa, Junzo, Okazaki, Toshiro
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2012
Предметы:
Lipids
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3501064/
https://ncbi.nlm.nih.gov/pubmed/23035115
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.416552
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