Caspase-dependent immunogenicity of doxorubicin-induced tumor cell death

Systemic anticancer chemotherapy is immunosuppressive and mostly induces nonimmunogenic tumor cell death. Here, we show that even in the absence of any adjuvant, tumor cells dying in response to anthracyclins can elicit an effective antitumor immune response that suppresses the growth of inoculated...

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Detalhes bibliográficos
Main Authors: Casares, Noelia, Pequignot, Marie O., Tesniere, Antoine, Ghiringhelli, François, Roux, Stéphan, Chaput, Nathalie, Schmitt, Elise, Hamai, Ahmed, Hervas-Stubbs, Sandra, Obeid, Michel, Coutant, Frédéric, Métivier, Didier, Pichard, Evelyne, Aucouturier, Pierre, Pierron, Gérard, Garrido, Carmen, Zitvogel, Laurence, Kroemer, Guido
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2005
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2212968/
https://ncbi.nlm.nih.gov/pubmed/16365148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20050915
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