Loss of C/EBPα cell cycle control increases myeloid progenitor proliferation and transforms the neutrophil granulocyte lineage

CCAAT/enhancer binding protein (C/EBP)α is a myeloid-specific transcription factor that couples lineage commitment to terminal differentiation and cell cycle arrest, and is found mutated in 9% of patients who have acute myeloid leukemia (AML). We previously showed that mutations which dissociate the...

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Main Authors: Porse, Bo T., Bryder, David, Theilgaard-Mönch, Kim, Hasemann, Marie S., Anderson, Kristina, Damgaard, Inge, Jacobsen, Sten Eirik W., Nerlov, Claus
Format: Artigo
Jezik:Inglês
Izdano: The Rockefeller University Press 2005
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2212897/
https://ncbi.nlm.nih.gov/pubmed/15983063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20050067
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