Defective NKT cell development in mice and humans lacking the adapter SAP, the X-linked lymphoproliferative syndrome gene product

SAP is an adaptor protein expressed in T cells and natural killer cells. It plays a critical role in immunity, as it is mutated in humans with X-linked lymphoproliferative syndrome (XLP), a fatal immunodeficiency characterized by an abnormal response to Epstein-Barr virus (EBV) infection. SAP intera...

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Bibliographic Details
Main Authors: Pasquier, Benoit, Yin, Luo, Fondanèche, Marie-Claude, Relouzat, Francis, Bloch-Queyrat, Coralie, Lambert, Nathalie, Fischer, Alain, de Saint-Basile, Geneviève, Latour, Sylvain
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2005
Subjects:
Brief Definitive Report
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2212840/
https://ncbi.nlm.nih.gov/pubmed/15738056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20042432
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