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Phosphorylation of histone deacetylase 7 by protein kinase D mediates T cell receptor–induced Nur77 expression and apoptosis

The molecular basis of thymocyte negative selection, a crucial mechanism in establishing central tolerance, is not yet resolved. Histone deacetylases (HDACs) have emerged as key transcriptional regulators in several major developmental programs. Recently, we showed that the class IIa member, HDAC7,...

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Detalhes bibliográficos
Main Authors: Dequiedt, Franck, Van Lint, Johan, Lecomte, Emily, Van Duppen, Viktor, Seufferlein, Thomas, Vandenheede, Jackie R., Wattiez, Ruddy, Kettmann, Richard
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2005
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2212830/
https://ncbi.nlm.nih.gov/pubmed/15738054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20042034
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