The Linkage of Innate to Adaptive Immunity via Maturing Dendritic Cells In Vivo Requires CD40 Ligation in Addition to Antigen Presentation and CD80/86 Costimulation

Dendritic cell (DC) maturation is an innate response that leads to adaptive immunity to coadministered proteins. To begin to identify underlying mechanisms in intact lymphoid tissues, we studied α-galactosylceramide. This glycolipid activates innate Vα14(+) natural killer T cell (NKT) lymphocytes, w...

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Main Authors: Fujii, Shin-ichiro, Liu, Kang, Smith, Caroline, Bonito, Anthony J., Steinman, Ralph M.
格式: Artigo
語言:Inglês
出版: The Rockefeller University Press 2004
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2212806/
https://ncbi.nlm.nih.gov/pubmed/15197224
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20040317
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