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Pax5 Activates Immunoglobulin Heavy Chain V to DJ Rearrangement in Transgenic Thymocytes

Mice deficient for the B cell–restricted transcription factor Pax5 show a defect in the V(H) to DJ(H) rearrangement step of immunoglobulin heavy chain gene assembly even though the expression of the V(D)J recombinase is not diminished in Pax5 (−/−) pro–B cells. To investigate whether Pax5 is limitin...

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Detalhes bibliográficos
Main Authors: Hsu, Lih-Yun, Liang, Hong-Erh, Johnson, Kristen, Kang, Chulho, Schlissel, Mark S.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2004
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2212727/
https://ncbi.nlm.nih.gov/pubmed/15007090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20032249
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