gp100/pmel 17 Is a Murine Tumor Rejection Antigen: Induction of “Self”-reactive, Tumoricidal T Cells Using High-affinity, Altered Peptide Ligand

Many tumor-associated antigens are nonmutated, poorly immunogenic tissue differentiation antigens. Their weak immunogenicity may be due to “self”-tolerance. To induce autoreactive T cells, we studied immune responses to gp100/pmel 17, an antigen naturally expressed by both normal melanocytes and mel...

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Bibliographic Details
Main Authors: Overwijk, Willem W., Tsung, Allan, Irvine, Kari R., Parkhurst, Maria R., Goletz, Theresa J., Tsung, Kangla, Carroll, Miles W., Liu, Chunlei, Moss, Bernard, Rosenberg, Steven A., Restifo, Nicholas P.
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 1998
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2212458/
https://ncbi.nlm.nih.gov/pubmed/9670040
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