Aminooxypentane-RANTES Induces CCR5 Internalization but Inhibits Recycling: A Novel Inhibitory Mechanism of HIV Infectivity

CCR5, a chemokine receptor expressed on T cells and macrophages, is the principal coreceptor for M-tropic HIV-1 strains. Recently, we described an NH(2)-terminal modification of the CCR5 ligand regulated on activation, normal T cell expressed and secreted (RANTES), aminooxypentane-RANTES (AOP-RANTES...

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Main Authors: Mack, Matthias, Luckow, Bruno, Nelson, Peter J., Cihak, Josef, Simmons, Graham, Clapham, Paul R., Signoret, Nathalie, Marsh, Mark, Stangassinger, Manfred, Borlat, Fréderic, Wells, Timothy N.C., Schlöndorff, Detlef, Proudfoot, Amanda E.I.
Format: Artigo
Jezik:Inglês
Izdano: The Rockefeller University Press 1998
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2212227/
https://ncbi.nlm.nih.gov/pubmed/9547333
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