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Mucosal Adjuvanticity and Immunogenicity of LTR72, a Novel Mutant of Escherichia coli Heat-labile Enterotoxin with Partial Knockout of ADP-ribosyltransferase Activity

Heat-labile Escherichia coli enterotoxin (LT) has the innate property of being a strong mucosal immunogen and adjuvant. In the attempt to reduce toxicity and maintain the useful immunological properties, several LT mutants have been produced. Some of these are promising mucosal adjuvants. However, s...

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Main Authors: Giuliani, Marzia Monica, Del Giudice, Giuseppe, Giannelli, Valentina, Dougan, Gordon, Douce, Gill, Rappuoli, Rino, Pizza, Mariagrazia
格式: Artigo
語言:Inglês
出版: The Rockefeller University Press 1998
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2212201/
https://ncbi.nlm.nih.gov/pubmed/9529328
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