cAMP/PKA Regulates Osteogenesis, Adipogenesis and Ratio of RANKL/OPG mRNA Expression in Mesenchymal Stem Cells by Suppressing Leptin

BACKGROUND: Mesenchymal stem cells (MSCs) are a pluripotent cell type that can differentiate into adipocytes, osteoblasts and other cells. The reciprocal relationship between adipogenesis and osteogenesis was previously demonstrated; however, the mechanisms remain largely unknown. METHODS AND FINDIN...

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Bibliographische Detailangaben
Hauptverfasser: Yang, Der-Chih, Tsay, Huey-Jen, Lin, Shan-Yang, Chiou, Shih-Hwa, Li, Mei-Jane, Chang, Tai-Jay, Hung, Shih-Chieh
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2008
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2212109/
https://ncbi.nlm.nih.gov/pubmed/18253488
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0001540
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