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C4b-binding protein binds to necrotic cells and DNA, limiting DNA release and inhibiting complement activation

After cell death, via apoptosis or necrosis, the uptake of dead cells by neighboring cells or phagocytes prevents the release of intracellular content. An array of molecules, including initiation molecules of the complement system, are involved in marking dead cells for uptake. After binding of thes...

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Bibliografske podrobnosti
Main Authors: Trouw, Leendert A., Nilsson, Sara C., Gonçalves, Isabel, Landberg, Göran, Blom, Anna M.
Format: Artigo
Jezik:Inglês
Izdano: The Rockefeller University Press 2005
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2212022/
https://ncbi.nlm.nih.gov/pubmed/15967823
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20050189
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