Immunoglobulin Class Switch Recombination Is Impaired in Atm-deficient Mice

Immunoglobulin class switch recombination (Ig CSR) involves DNA double strand breaks (DSBs) at recombining switch regions and repair of these breaks by nonhomologous end-joining. Because the protein kinase ataxia telengiectasia (AT) mutated (ATM) plays a critical role in DSB repair and AT patients s...

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Auteurs principaux: Lumsden, Joanne M., McCarty, Thomas, Petiniot, Lisa K., Shen, Rhuna, Barlow, Carrolee, Wynn, Thomas A., Morse, Herbert C., Gearhart, Patricia J., Wynshaw-Boris, Anthony, Max, Edward E., Hodes, Richard J.
Format: Artigo
Langue:Inglês
Publié: The Rockefeller University Press 2004
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2211853/
https://ncbi.nlm.nih.gov/pubmed/15504820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20041074
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