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Immunoglobulin Class Switch Recombination Is Impaired in Atm-deficient Mice
Immunoglobulin class switch recombination (Ig CSR) involves DNA double strand breaks (DSBs) at recombining switch regions and repair of these breaks by nonhomologous end-joining. Because the protein kinase ataxia telengiectasia (AT) mutated (ATM) plays a critical role in DSB repair and AT patients s...
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| 主要な著者: | , , , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
The Rockefeller University Press
2004
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2211853/ https://ncbi.nlm.nih.gov/pubmed/15504820 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20041074 |
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