Deuterium exchange and mass spectrometry reveal the interaction differences of two synthetic modulators of RXRα LBD

Protein amide hydrogen/deuterium (H/D) exchange was used to compare the interactions of two antagonists, UVI 2112 and UVI 3003, with that of the agonist, 9-cis-retinoic acid, upon binding to the human retinoid X receptor alpha ligand-binding domain (hRXRα LBD) homodimer. Analysis of the H/D content...

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Bibliografiset tiedot
Päätekijät: Yan, Xuguang, Pérez, Efrén, Leid, Mark, Schimerlik, Michael I., de Lera, Angel R., Deinzer, Max L.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Cold Spring Harbor Laboratory Press 2007
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2211688/
https://ncbi.nlm.nih.gov/pubmed/17905826
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.073019707
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