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Deuterium exchange and mass spectrometry reveal the interaction differences of two synthetic modulators of RXRα LBD
Protein amide hydrogen/deuterium (H/D) exchange was used to compare the interactions of two antagonists, UVI 2112 and UVI 3003, with that of the agonist, 9-cis-retinoic acid, upon binding to the human retinoid X receptor alpha ligand-binding domain (hRXRα LBD) homodimer. Analysis of the H/D content...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2211688/ https://ncbi.nlm.nih.gov/pubmed/17905826 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1110/ps.073019707 |
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